Skip to Content
MilliporeSigma
All Photos(4)

Key Documents

View All Documentation

SAB4200628

Sigma-Aldrich

Anti-CNTNAP2 (Internal) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

5430425M22Rik, AUTS15, CASPR2, CDFE, CG6827, CNTNAP2, CT21123, Cell recognition molecule Caspr2 (CASPR2), Dmel CG6827, Dnrx, KIAA0868, LOC559157, NRX, NRXN4, Nrx-IV, Nx IV, PTHSL1, contactin associated protein-like 2, l(3)68Ff, l(3)rsg23, mKIAA0868, rsg23

Sign Into View Organizational & Contract Pricing
All Photos(4)

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

form

buffered aqueous solution

mol wt

~150 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

immunoblotting: 1-2 μg/mL using whole extracts of rat brain and 293T cells overexpressing human CNTNAP2
immunoprecipitation (IP): 5-10 μg using extracts of mouse brain

UniProt accession no.

Q9UHC6

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CNTNAP2(26047)
mouse ... Cntnap2(66797)
rat ... Cntnap2(500105)

General description

Contactin associated protein-like 2 (CNTNAP2) is a synaptic protein which is part of the neurexin superfamily. It is a transmembrane protein expressed in myelinated axons. The gene encoding this protein is localized on human chromosome 7.

Specificity

Anti-CNTNAP2 (internal) recognizes human, mouse and rat CNTNAP2.

Immunogen

synthetic peptide corresponding to an internal sequence of human CNTNAP2

Application

Anti-CNTNAP2 (Internal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

Biochem/physiol Actions

Contactin associated protein-like 2 (CNTNAP2) controls the spatial clustering of voltage-gated potassium channels Kv1.1 and Kv1.2. It has been reported that alteration in the CNTNAP2 gene expression causes mental retardation, autistic behavior, seizures and microcephaly.
Mutations in the CNTNP2 is also implicated in the Pitt-Hopkins like syndrome. There are neurobiological, genetic and imaging evidences in both knockout mice and in humans bearing CNTNAP2 mutations, that this gene is a risk factor for ASD (Autism spectrum disorder) and related neurodevelopmental disorders.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
054M4761V
054M4761V

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

What does CNTNAP2 reveal about autism spectrum disorder?
Penagarikano O and Geschwind DH
Trends in Molecular Medicine, 18(3), 156-163 (2012)
CNTNAP2 and NRXN1 are mutated in autosomal-recessive Pitt-Hopkins-like mental retardation and determine the level of a common synaptic protein in Drosophila
Zweier C, et al.
American Journal of Human Genetics, 85(5), 655-666 (2009)
Martin Poot et al.
Neurogenetics, 11(1), 81-89 (2009-07-08)
Patients with autism spectrum disorder (ASD) frequently harbour chromosome rearrangements and segmental aneuploidies, which allow us to identify candidate genes. In a boy with mild facial dysmorphisms, speech delay and ASD, we reconstructed by karyotyping, FISH and SNP array-based segmental
Srirangan Sampath et al.
PloS one, 8(10), e77906-e77906 (2013-10-23)
Multiple lines of genetic evidence suggest a role for CNTNAP2 in autism. To assess its population impact we studied 2148 common single nucleotide polymorphisms (SNPs) using transmission disequilibrium test (TDT) across the entire ~3.3 Mb CNTNAP2 locus in 186 (408
Christian Clemm von Hohenberg et al.
Journal of psychiatric research, 47(10), 1349-1356 (2013-07-23)
CNTNAP2 is a gene on chromosome 7 that has shown associations with autism and schizophrenia, and there is evidence that it plays an important role for neuronal synchronization and brain connectivity. In this study, we assessed the relationship between Diffusion

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service