The exosome component 1 (EXOSC1) gene is located on human chromosome 10q24.1.
The gene EXOSC1 (exosome component 1) encodes one of the nine core subunits of the exosome complex. The protein is also referred to as Csl4 and has high affinity for RNA.
Biochem/physiol Actions
The exosome complex facilitates the splicing and degradation of mRNAs and non-coding RNAs. It is also essential for epigenetic gene regulation. It endogenously suppresses erythroid maturation. Within the complex, Exosc1 (exosome component 1) associates with Exosc6 to stabilize the complex. The binding of Exosc10 to Exosc1, Exosc6, and Exosc8 enhances the activity of the complex and positions Exosc1 for RNA binding.
Other Notes
synthetic peptide corresponding to a sequence at the internal region of human EXOSC1 conjugated to KLH
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.
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International journal of oncology, 41(6), 2038-2046 (2012-10-02)
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The RNA-Degrading Exosome Complex Is an Endogenous Suppressor of Erythroid Maturation.
Complex genetic networks control hematopoietic stem cell differentiation into progenitors that give rise to billions of erythrocytes daily. Previously, we described a role for the master regulator of erythropoiesis, GATA-1, in inducing genes encoding components of the autophagy machinery. In
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