SAB4200613
Monoclonal Anti-Biglycan antibody from mouse
clone 905A7, purified immunoglobulin
Synonym(s):
BGN, Bone/cartilage proteoglycan I, Leucine-rich PG I, PG-S1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
905A7, monoclonal
species reactivity
human, bovine
concentration
1 mg/mL
technique(s)
immunohistochemistry: 5-10 μg/test using using human kidney tissue sections.
isotype
IgG1
UniProt accession no.
Storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
bovine ... BGN(280733)
General description
Biglycan (BGN) is class I small leucine rich proteoglycans (SLRP), encoded by the gene mapped to human chromosome Xq28. The encoded protein is characterized with two chondroitin sulfate glycosaminoglycan (GAG) chains attached near its NH2 terminus. Biglycan is expressed as a constituent of extracellular matrices in various tissues.
Monoclonal Anti-Biglycan (mouse IgG1 isotype) is derived from the hybridoma 905A7 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.
Specificity
Monoclonal Anti-Biglycan recognizes human and bovine biglycan.
Application
Monoclonal Anti-Biglycan antibody from mouse may be used in:
- immunoblotting
- immunohistochemistry
- enzyme-linked immunosorbent assay (ELISA)
Biochem/physiol Actions
In vitro studies state that biglycan (BGN) plays a vital role in the connective tissue metabolism by interacting with collagen fibrils-4 and transforming growth factor (TGF)-β and might also enhance neuronal survival. It also plays a crucial role in maintaining the structural integrity of the aortic wall. Variation in the gene expression leads to X-linked, severe, syndromic form of thoracic aortic aneurysm and dissection (TAAD), including hypertelorism, pectus deformity, joint hypermobility, contractures, and mild skeletal dysplasia. In addition, mutation in the gene is associated with the development of Happle syndrome.
Biglycan signaling provides an important link between innate and adaptive immunity. This protein also plays a crucial role in the regulation of inflammation, bone growth, and muscle development and regeneration. Biglycan is involved in various human diseases, such as asthma, atherosclerosis, cancer, diabetes, and kidney disease.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For extended storage, freezeat -20 °Cin working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify thesolution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Kristin Moreth et al.
Cell cycle (Georgetown, Tex.), 11(11), 2084-2091 (2012-05-15)
Inflammation is not only a defensive mechanism against microbial invasion, but also frequently represents a critical response to tissue injury under sterile conditions. It is now well established that tissue injury leads to the release of endogenous molecules of intra-
Liliana Schaefer
Journal of the American Society of Nephrology : JASN, 22(7), 1200-1207 (2011-07-02)
Research over the past 2 decades provides ample evidence that small leucine-rich proteoglycans (SLRPs; such as decorin, biglycan, fibromodulin, and lumican) of the extracellular matrix are deeply involved in the regulation of inflammatory and fibrotic renal disorders. Initial efforts in
Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections
Meester JA, et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 19(4), 386-386 (2017)
Biglycan knockout mice: New models for musculoskeletal diseases
Young MF, et al.
Glycoconjugate Journal, 19(4-5), 257-262 (2002)
Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
Xu T, et al.
Nature Genetics, 20(1), 78-78 (1998)
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