Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an adenosine triphosphate (ATP)-dependent chromatin-remodeling factor. It belongs to the CHD family of proteins. CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD1 gene is mapped on the human chromosome at 5q15-q21.1.
Specificity
Anti- CHD1 recognizes human and mouse CHD1.
Immunogen
synthetic peptide corresponding to an internal region of human CHD1 , conjugated to KLH.
Application
Anti-CHD1 antibody from rabbit may be used in immunoblotting.
Biochem/physiol Actions
Chromodomain-helicase-DNA-binding protein 1 (CHD1) is required for maintaining open chromatin and pluripotency in embryonic stem cells. It is involved in gametogenesis. CHD1 plays a role in the incorporation of H3.3 into male pronucleus during the process of decondensation post-fertilization.
Physical form
a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide
Storage and Stability
For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
New methods for the genome-wide analysis of chromatin are providing insight into its roles in development and their underlying mechanisms. Current studies indicate that chromatin is dynamic, with its structure and its histone modifications undergoing global changes during transitions in
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