SAB4200584

Anti-COG2 antibody produced in rabbit

IgG fraction of antiserum

• Synonym(s): Anti-Component of oligomeric Golgi complex 2, Anti-LDLC, Anti-Low density lipoprotein receptor defect C-complementing protein
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~83 kDa
• species reactivity: human
• technique(s): immunoblotting: 1:1000-1:2000 using whole extracts of hamster CHO cells.; immunoprecipitation (IP): 2.5-5.0 μL using lysates of human HeLa cells; indirect immunofluorescence: 1:2,500-1:5,000 using human HeLa cells.
• UniProt accession no.: Q14746
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... COG2(22796)

Description

General description

Conserved oligomeric Golgi (COG) complex 2 is also known as LDLC. COG complex is a multi-subunit protein complex, composed of eight distinct subunits. This protein is highly conserved with two heterotrimeric groups, Cog2-Cog3- Cog4 and Cog5-Cog6-Cog7 in its structure.

Immunogen

synthetic peptide corresponding to the C-terminal region of human COG2, conjugated to KLH. The corresponding sequence is identical in monkey and bovine and differs by four amino acids in rat and mouse COG2.

Application

Anti-COG2 antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem/physiol Actions

Conserved oligomeric Golgi (COG) complex 2 regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells. COG2 is needed for normal Golgi morphology and function. COG2 interacts with p115 (golgin), a vesicle tethering protein that functions in endoplasmic reticulum-Golgi trafficking. This interaction is required for Golgi integrity.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable