SAB4200568
Anti-COG4 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
Synonym(s):
Anti-CDG2J, Anti-COD1, Anti-COG complex subunit 4, Anti-COMPONENT OF OLIGOMERIC GOLGI COMPLEX 4
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~84 kDa
species reactivity
mouse, human, rat
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.
western blot: 2.5-5.0 μg/mL using whole extracts of rat liver.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... COG4(25839)
mouse ... Cog4(102339)
rat ... Cog4(361407)
General description
Conserved oligomeric Golgi complex 4 (COG4) is a member of the conserved oligomeric Golgi (COG) complex. COG complex comprises eight distinct subunits Cog2-Cog3- Cog4 (lobe A) and Cog5-Cog6-Cog7 (lobe B). These two heterotrimeric groups are linked by the dimeric group formed by Cog1 and Cog8. COG4 gene is mapped to human chromosome 16q22.1.
Specificity
Anti-COG4 recognizes human and rat COG4.
Immunogen
peptide corresponding to an internal region of human COG4, conjugated to KLH. The corresponding sequence is identical in mouse, rat, dog and monkey COG4.
Application
Anti-COG4 antibody produced in rabbit may be used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Conserved oligomeric Golgi complex 4 (COG4) is needed for normal Golgi function. COG4 is implicated in Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) pairing. It is also and Golgi-to-endoplasmic reticulum (ER) retrograde transport via its interaction with the suppressor of loss of YPT1 protein 1 (Sly1). Defects in the COG4 gene is implicated congenital disorder of glycosylation type II (CDG-II). Mutation in the COG4 gene is also implicated in Saul-Wilson syndrome with vesicular trafficking disruption.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage,clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Orly Laufman et al.
The EMBO journal, 28(14), 2006-2017 (2009-06-19)
The crucial roles of Sec1/Munc18 (SM)-like proteins in membrane fusion have been evidenced in genetic and biochemical studies. SM proteins interact directly with SNAREs and contribute to SNARE pairing by a yet unclear mechanism. Here, we show that the SM
Pamela A Norton et al.
World journal of gastroenterology, 25(23), 2947-2960 (2019-06-30)
Changes in N-linked glycosylation have been observed in the circulation of individuals with hepatocellular carcinoma. In particular, an elevation in the level of core fucosylation has been observed. However, the mechanisms through which core fucose is increased are not well
Ellen Reynders et al.
Human molecular genetics, 18(17), 3244-3256 (2009-06-06)
The conserved oligomeric Golgi (COG) complex is a hetero-octameric complex essential for normal glycosylation and intra-Golgi transport. An increasing number of congenital disorder of glycosylation type II (CDG-II) mutations are found in COG subunits indicating its importance in glycosylation. We
Carlos R Ferreira et al.
American journal of human genetics, 103(4), 553-567 (2018-10-06)
The conserved oligomeric Golgi (COG) complex is involved in intracellular vesicular transport, and is composed of eight subunits distributed in two lobes, lobe A (COG1-4) and lobe B (COG5-8). We describe fourteen individuals with Saul-Wilson syndrome, a rare form of
Rita Quental et al.
BMC evolutionary biology, 10, 212-212 (2010-07-17)
The Conserved Oligomeric Golgi (COG) complex is an eight-subunit assembly that localizes peripherally to Golgi membranes and is involved in retrograde vesicular trafficking. COG subunits are organized in two heterotrimeric groups, Cog2, -3, -4 and Cog5, -6, -7, linked by
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