SAB4200460

Anti-Arc (C-terminal) antibody produced in rabbit

IgG fraction of antiserum

• Synonym(s): Anti-Activity-regulated cytoskeleton-associated protein, Anti-Arc3.1, Anti-Arg3.1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~55 kDa
• species reactivity: human, mouse
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• technique(s): western blot: 1:2000-1:3000 using mouse brain extracts (P2 fraction); western blot: 1:3000-1:5000 using lysates of HEK-293T cells overexpressing human Arc
• UniProt accession no.: Q7LC44
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ARC(23237) ; mouse ... Arc(11838)

Description

General description

Activity-regulated cytoskeleton-associated protein (ARC) encodes a growth factor and is an immediate early gene (IEG) that is enriched in brain. It is also known as Arg3.1.

Immunogen

synthetic peptide corresponding to a sequence at the C-terminus of human Arc, conjugated to KLH. The corresponding sequence is highly conserved (89% sequence identity) in rat and mouse Arc.

Application

Anti-Arc (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Activity-regulated cytoskeleton-associated protein (ARC) is associated with synaptic plasticity and normal development in the central nervous system (CNS) induced by neuronal activity. Arc expression is tightly controlled by neuronal activity and its mRNA is rapidly localized to neuronal dendrites and spines where it undergoes local translation. Arc induction is required for late long-term potentiation (LTP) and memory consolidation, as well as LTP-induced cofilin phosphorylation and F-actin stabilization. Arc is known to regulate endocytosis of AMPA receptors mediated interaction with endophilin 3 and dynamin 2, notch signalling and spine morphology.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable