SAB4200456

Anti-EXOSC7 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(s): Anti-EAP1, Anti-Exosome complex component RRP42, Anti-Exosome complex exonuclease RRP42, Anti-Exosome component 7, Anti-RRP42, Anti-Ribosomal RNA-processing protein 42, Anti-hRrp42p, Anti-p8
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~34 kDa
• species reactivity: human
• concentration: ~1.0 mg/mL
• technique(s): immunoprecipitation (IP): 5-10 μg using lysates of human HeLa cells; indirect immunofluorescence: 2.5-5.0 μg/mL using human HeLa; cells; western blot: 1-2 μg/mL using whole extracts of HEK-293T; cells over-expressing human EXOSC7
• UniProt accession no.: Q15024
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... EXOSC7(23016)

Description

General description

Exosome component 7 (EXOSC7) protein is a non-catalytic component of the eukaryotic RNA exosome. The exosome is an evolutionary conserved multisubunit 3′ to 5′ exoribonuclease complex that exists both in the nucleus and cytoplasm. EXOSC7 protein is present at higher levels in epidermal progenitor cells. This protein forms the hexameric ring structure unit of the eukaryotic exosome. EXOSC7 gene is located on the human chromosome 3p21.31.

Specificity

Anti-EXOSC7 (C-terminal) recognizes human EXOSC7.

Immunogen

peptide corresponding to the C-terminal region of human EXOSC7, conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse and
rat.

Application

Anti-EXOSC7 (C-terminal) antibody produced in rabbit may be used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem/physiol Actions

Exosome component 7 (EXOSC7) is involved in blocking the premature differentiation of progenitor cells. Exosome complex is involved in the degradation and processing of cellular RNA.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable