SAB4200449

Anti-SOX11 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(s): Anti-SRY (sex determining region Y)-box 11
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• concentration: ~1.0 mg/mL
• technique(s): immunoprecipitation (IP): 5-10 μg using lysates of HEK-293T cells overexpressing human SOX11.; indirect immunofluorescence: 5-10 μg/mL using human HeLa cells.; western blot: 0.5-1.0 μg/mL using whole extracts of HEK-293T cells overexpressing human tagged-SOX11 (~72 kDa).
• UniProt accession no.: P35716
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SOX11(6664)

Description

General description

Sex determining region Y (SRY)-box 11 (SOX11) protein is a member of the SRY-related high mobility group (HMG)-box (SOX) family of transcription factors. This protein is expressed in adult immature neurons but is normally not expressed in any other adult tissue. SOX11 gene is mapped on the human chromosome at 2p25.2.

Specificity

Anti-SOX11 recognizes human SOX11.

Immunogen

peptide corresponding to an internal region of human SOX11, conjugated to KLH. The corresponding sequence is identical in monkey and pig and differs by 3 amino acids in mouse and rat.

Application

Anti-SOX11 antibody produced in rabbit may be used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem/physiol Actions

Sex determining region Y (SRY)-box 11 (SOX11) is involved in the regulation of tissue remodeling during embryonic development of the central nervous system and the determination of cell fate. This protein plays a role in tumorigenesis. SOX11 protein acts as a biomarker in mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL) and Burkitt lymphomas (BL). Upregulation of the SOX11 gene is associated with ovarian cancer, medulloblastomas, gliomas and brain tumor.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable