SAB4200441
Anti-COG6 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
Synonym(s):
Anti-COD2, Anti-Component of oligomeric golci complex 6
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~70 kDa
species reactivity
mouse, human, rat
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 10-20 μg using lysates of human HeLa cells.
western blot: 0.5-1.0 μg/mL using whole extracts of HEK-293T cells overexpressing human COG6.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... COG6(57511)
mouse ... Cog6(67542)
rat ... Cog6(310411)
General description
The conserved oligomeric Golgi complex 6 (COG6) is a component of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex is made up of eight distinct subunits organized in two heterotrimeric groups, COG2-COG3-COG4 and COG5-COG6-COG7, which are linked via the dimeric group formed by COG1 and COG8. COG6 gene is located on the human chromosome at 13q14.11.
Specificity
Anti-COG6 recognizes human COG6.
Immunogen
peptide corresponding to an internal region of human COG6, conjugated to KLH. The corresponding sequence is identical in mouse, rat and bovine COG6.
Application
Anti-COG6 antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
The conserved oligomeric Golgi complex 6 (COG6) subunit is associated with the trafficking intermediates that carry Golgi glycosyltransferases. This protein facilitates the interaction of COG complex with the target membrane (t-SNARE) syntaxin 6. COG6-lacking cells exhibit reduced steady-state levels of syntaxin 6 and attenuated endosome-to-trans-Golgi network (TGN) retrograde trafficking. Inadequacy of COG6 leads to a combined N- and O-glycosylation deficiency of the congenital disorders of glycosylation known as CDG-IIL (COG6-CDG).
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Guoqiang Li et al.
European journal of medical genetics, 62(1), 44-46 (2018-05-02)
COG6-CDG is a rare autosomal recessive disease of congenital disorders of glycosylation (CDG) caused by deficiency of subunit 6 of the conserved oligomeric Golgi complex (COG6), which is characterized by growth retardation, developmental disability, microcephaly, liver and gastrointestinal disease, recurrent
Irina D Pokrovskaya et al.
Glycobiology, 21(12), 1554-1569 (2011-03-23)
Cell surface lectin staining, examination of Golgi glycosyltransferases stability and localization, and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analysis were employed to investigate conserved oligomeric Golgi (COG)-dependent glycosylation defects in HeLa cells. Both Griffonia simplicifolia lectin-II and Galanthus nivalus
Orly Laufman et al.
The Journal of cell biology, 194(3), 459-472 (2011-08-03)
The conserved oligomeric Golgi (COG) complex has been implicated in the regulation of endosome to trans-Golgi network (TGN) retrograde trafficking in both yeast and mammals. However, the exact mechanisms by which it regulates this transport route remain largely unknown. In
Jürgen Lübbehusen et al.
Human molecular genetics, 19(18), 3623-3633 (2010-07-08)
Deficiency of subunit 6 of the conserved oligomeric Golgi (COG6) complex causes a new combined N- and O-glycosylation deficiency of the congenital disorders of glycosylation, designated as CDG-IIL (COG6-CDG). The index patient presented with a severe neurologic disease characterized by
Rita Quental et al.
BMC evolutionary biology, 10, 212-212 (2010-07-17)
The Conserved Oligomeric Golgi (COG) complex is an eight-subunit assembly that localizes peripherally to Golgi membranes and is involved in retrograde vesicular trafficking. COG subunits are organized in two heterotrimeric groups, Cog2, -3, -4 and Cog5, -6, -7, linked by
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