Conserved Oligomeric Golgi complex 7 (COG7) protein belongs to the COG complex. COG complex contains eight distinct subunits arranged in two heterotrimeric groups, COG2, 3, 4 and COG5, 6, 7 which are linked by a dimeric group formed by COG1 and COG8. COG complex is an evolutionarily conserved multi-subunit protein complex. The COG7 gene is mapped on the human chromosome at 16p12.2.
Specificity
Anti-COG7 (N-terminal) recognizes human, mouse and rat COG7.
Immunogen
peptide corresponding to the N-terminal region of human COG7, conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat COG7.
Application
Anti-COG7 (N-terminal) antibody produced in rabbit may be used in immunoblotting.
Biochem/physiol Actions
Conserved Oligomeric Golgi complex (COG) plays a role in regulating membrane trafficking and maintenance of the eukaryotic Golgi glycosylation system. COG7 protein functions in retrograde vesicular trafficking. Mutations in the COG7 gene are associated with congenital disorder of glycosylation, type IIe.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
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Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
European journal of human genetics : EJHG, 15(6), 638-645 (2007-03-16)
We describe the clinical and biochemical characteristics in three patients from two different families diagnosed with Congenital Disorder of Glycosylation type IIe owing to a defect in Conserved Oligomeric Golgi complex (COG)7; one of the eight subunits of the COG.
We recently described a complex population of spermatozoal coding RNAs that are delivered to the oocyte on fertilization. These are derived throughout spermatogenesis, representing a record of past events. Recently, evidence has been provided that micro-RNAs are present in testes
European journal of medical genetics, 52(5), 303-305 (2009-07-07)
We describe a patient homozygous for a novel mutation in COG7, coding for one of the subunits of the Conserved Oligomeric Golgi complex, involved in retrograde vesicular trafficking. His brother showed a similar clinical syndrome and glycosylation defect but no
The Conserved Oligomeric Golgi (COG) complex is an eight-subunit assembly that localizes peripherally to Golgi membranes and is involved in retrograde vesicular trafficking. COG subunits are organized in two heterotrimeric groups, Cog2, -3, -4 and Cog5, -6, -7, linked by
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