SAB4200426

Anti-COG3 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(s): Anti-COG complex subunit 3, tethering factor SEC34, Anti-SEC34, Anti-component of oligomeric golgi complex 3, Anti-conserved oligomeric Golgi complex subunit 3, Anti-p94, Anti-vesicle-docking protein SEC34 homolog
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~94 kDa
• species reactivity: mouse, rat, human
• concentration: ~1.0 mg/mL
• technique(s): western blot: 1-2 μg/mL using whole extracts of human HEK-293T, mouse NIH-3T3 and rat PC12 cells.
• UniProt accession no.: Q96JB2
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... COG3(83548) ; mouse ... Cog3(338337) ; rat ... Cog3(361073)

Description

General description

The conserved oligomeric Golgi complex 3 (COG3) protein is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex contains eight distinct subunits organized in two heterotrimeric groups, COG2-COG3-COG4 and COG5-COG6-COG7, which are linked by the dimeric group formed by COG1 and COG8. The COG3 gene is mapped on the human chromosome at 13q14.13.

Specificity

Anti-COG3 recognizes human, mouse and rat COG3.

Immunogen

a peptide corresponding to an internal region of human COG3, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey and bovine COG3.

Application

Anti-COG3 antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

Conserved oligomeric Golgi complex 3 (COG3) protein is involved in the endoplasmic reticulum (ER)-Golgi membrane trafficking. COG3 protein depletion hinders vesicle-mediated Golgi retrograde trafficking in HeLa cells and results in the accumulation of COG complex-dependent vesicles in the cell cytoplasm.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable