SAB4200425

Anti-COG1 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(s): Anti-CDG2G, Anti-COG complex subunit 1, Anti-LDLB, Anti-component of oligomeric golgi complex 1, Anti-conserved oligomeric Golgi complex subunit 1, Anti-low density lipoprotein receptor defect B complementing
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~110 kDa
• species reactivity: rat, mouse, human
• concentration: ~1.0 mg/mL
• technique(s): western blot: 2.5-5.0 μg/mL using whole extracts of human HepG2 and rat PC12 cells.
• UniProt accession no.: Q8WTW3
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... COG1(9382) ; mouse ... Cog1(16834) ; rat ... Cog1(303652)

Description

General description

The conserved oligomeric Golgi complex 1 (COG1) protein is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex contains eight subunits organized in two heterotrimeric groups, COG-2-COG3-COG4 and COG5-COG6-COG7, which are linked by the dimeric group formed by COG1 and COG8. The COG1 gene is located on the human chromosome at 17q25.1.

Specificity

Anti-COG1 (N-terminal) recognizes human and rat COG1.

Immunogen

peptide corresponding to the N-terminal region of human COG1, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey and bovine COG1.

Application

Anti-COG1 (N-terminal) antibody produced in rabbit may be used in immunoblotting.

Biochem/physiol Actions

The conserved oligomeric Golgi complex 1 (COG1) protein is needed for normal Golgi function. It is required for steps in the normal medial and trans-Golgi-associated processing of glycoconjugates. It also plays a role in the organization of the Golgi-localized complex. In humans, mutations in the COG subunit cause novel types of congenital disorders of glycosylation.

Physical form

solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable