SAB4200409

Anti-Dysbindin antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Synonym(s): Anti-DBND, Anti-DTNBP1, Anti-HPS7, Anti-My031, Anti-SDY
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~60 kDa
• species reactivity: rat, mouse, human
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• concentration: ~1.0 mg/mL
• technique(s): indirect immunofluorescence: 5-10 μg/mL using PC12 cells.; western blot: 1-2 μg/mL using HEK-293T cells overexpressing human dysbindin.
• UniProt accession no.: Q96EV8
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... DTNBP1(84062) ; mouse ... Dtnbp1(94245) ; rat ... Dtnbp1(641528)

Description

General description

Dysbindin (also known as DTNBP1) is a neuronal protein. DTNBP1 mRNA is widely expressed in the brain, located in postsynaptic densities and synaptic vesicles of neurons. Dysbindin-1 is coded by dystrobrevin-binding protein 1 gene (DTNBP1), that is located on the short (p) arm of human chromosome 6.

Immunogen

synthetic peptide corresponding to a sequence at an internal region of human dysbindin, conjugated to KLH. The corresponding sequence is identical in human dysbindin isoforms b, c and in rat and mouse dysbindin.

Application

Anti-Dysbindin antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

Dysbindin (DTNBP1) controls synaptic homeostasis by regulating the exocytosis and formation of synaptic vesicles. The DTNBP1 gene has been linked to schizophrenia in humans. Polymorphism of DTNBP1 confers susceptibility to schizophrenia through a decreased expression of dysbindin. Mutations in the human DTNBP1 gene causes a novel form of Hermansky-Pudlak syndrome (HPS) called HPS-7, a genetically heterogeneous disorder caused by abnormal vesicle trafficking to lysosomes and related organelles. Dysbindin, a constituent of the biogenesis of lysosome-related organelles complex 1 (BLOC-1), controls the trafficking of proteins in the lysosomal pathway, suggesting that dysbindin has a role in the biogenesis of lysosome-related organelles.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable