SAB4200397

Anti-EXOSC4 antibody produced in rabbit

~1 mg/mL, affinity isolated antibody

• Synonym(s): Anti-Exosome complex component, Anti-Exosome complex exonuclease RRP41, Anti-Exosome component 4, RRP41, Anti-RRP41, Anti-RRP41A, Anti-Rrp41p, Anti-SKI6, Anti-Ski6p, Anti-hRrp41p, Anti-p12A
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• mol wt: antigen ~26 kDa
• species reactivity: human, mouse
• concentration: ~1 mg/mL
• technique(s): immunoprecipitation (IP): 2.5-5 μg using lysates of human HeLa cells; indirect immunofluorescence: 5-10 μg/mL using human HeLa cells; western blot: 2-4 μg/mL using whole extracts of mouse Hepa1-6 cells
• UniProt accession no.: Q9NPD3
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... EXOSC4(54512) ; mouse ... Exosc4(109075)

Description

General description

Exosome Component 4 (EXOSC4), also known as RNA-processing protein 41 (RRP41), is a non-catalytic component of the eukaryotic RNA exosome. The eukaryotic exosome is a 400kDa complex composed of a nine subunit catalytically inert core provides structural support and facilitates substrate recognition, and two associated catalytic subunits.

The gene EXOSC4 (exosome component 4) is mapped to human chromosome 8q24.3. The encoded protein is present in the cytoplasm as well as nucleus and has a RNase pleckstrin homology (PH) domain.

Immunogen

peptide corresponding to the N-terminal region of human EXCSC4, conjugated to KLH. The corresponding sequence differs by one amino acid in mouse and rat.

Application

Anti-EXOSC4 antibody produced in rabbit has been used in various immunochemical techniques including immunoblotting, immunoprecipitation and immunofluorescence.

Biochem/physiol Actions

EXOSC4 (exosome component 4) is a core component of the exosome complex and is required for the stability of the complex. The exosome complex exhibits 3′-5′ exoribonuclease function. EXOSC4 lacks ribonuclease activity but is involved in mRNA turnover.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable