SAB4200396
Anti-EXOSC2 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
Synonym(s):
Anti-Exosome component 2, p7, Anti-HRRP4P, Anti-RRP4, Anti-RRP4P
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~55 kDa
species reactivity
rat, mouse, human
concentration
~1.0 mg/mL
technique(s)
western blot: 2.5-5.0 μg/mL using whole extracts of human Jurkat, mouse A20 and rat PC12 cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EXOSC2(23404)
mouse ... Exosc2(227715)
rat ... Exosc2(366017)
General description
EXOSC2 (Exosome component 2) is a non-catalytic subunit of the eukaryotic RNA exosome. It is localized in the nucleus and in the cytoplasm.
Exosome component 2 (EXOSC2) gene is mapped to human chromosome 9q34. It comprises S1 RNA-binding domain and is a part of the three-subunit cap and a core exosome component.
Specificity
Anti-EXOSC2 recognizes human, mouse and rat EXOSC2.
Immunogen
peptide corresponding to the N-terminal region of human EXOSC2, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey, bovine, pig and dog.
Application
Anti-EXOSC2 antibody produced in rabbit is suitable for western blot at a concentration of 2.5-5.0μg/mL using whole extracts of human Jurkat, mouse A20 and rat PC12 cells.
Biochem/physiol Actions
EXOSC2 (Exosome component 2) is associated with several cellular processes such as rRNA processing, RNA degradation from the 3′ end, 3′ to 5′ decay of the mRNA body after its deadenylation. Exosome complex is an ~400kDa multimeric complex, which plays a vital role in substrate recognition. EXOSC2 functions as a cofactor in the maintenance of human exosome integrity and efficient degradation and/or metabolism of various RNA classes.
Exosome component 2 (EXOSC2) gene mutations leads to alterations in its RNA binding and recruiting abilities. Biallelic mutations is implicated in facial gestalt and other associated anomalies.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8°C for up to one month. For extended storage freeze in workingaliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Jungwon Huh et al.
Annals of hematology, 90(11), 1255-1264 (2011-03-09)
The current study investigated molecular cytogenetic characteristics of chronic myeloid leukemia (CML) using genome-wide, single nucleotide polymorphism arrays (SNP-A) capable of detecting cryptic submicroscopic genomic aberrations. Genome-Wide Human SNP 6.0 Array (Affymetrix, CA, USA) was performed in 118 patients having
Nataliya Di Donato et al.
Journal of medical genetics, 53(6), 419-425 (2016-02-05)
Retinitis pigmentosa in combination with hearing loss can be a feature of different Mendelian disorders. We describe a novel syndrome caused by biallelic mutations in the 'exosome component 2' (EXOSC2) gene. Clinical ascertainment of three similar affected patients followed by
Derrick J Morton et al.
RNA (New York, N.Y.), 24(2), 127-142 (2017-11-03)
The RNA exosome is an evolutionarily conserved, ribonuclease complex that is critical for both processing and degradation of a variety of RNAs. Cofactors that associate with the RNA exosome likely dictate substrate specificity for this complex. Recently, mutations in genes
Erwin L van Dijk et al.
RNA (New York, N.Y.), 13(7), 1027-1035 (2007-06-05)
The human exosome is a 3'-5' exoribonuclease complex that functions both in the nucleus and in the cytoplasm to either degrade or process RNA. Little is known yet about potential differences among core exosome complexes in these different cellular compartments
Daniel L Kiss et al.
RNA (New York, N.Y.), 16(4), 781-791 (2010-02-27)
The RNA processing exosome complex was originally defined as an evolutionarily conserved multisubunit complex of ribonucleases responsible for the processing and/or turnover of stable RNAs. The exosome complex is also involved in the surveillance of mRNAs in both the nucleus
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