UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) is a large soluble protein of the endoplasmic reticulum (ER). It consists of an N-terminal folding sensor domain responsible for the selection of misfolded glycoproteins and a C-terminal catalytic domain that transfers glucose residues.
Immunogen
synthetic peptide corresponding to the C-terminal region of human UGGT1, conjugated to KLH. The antibody is affinity-purified using the immunizing peptide immobilized on agarose.
Application
Anti-UGGT1 (human) antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) selectively re-glucosylates unfolded glycoproteins. It provides quality control for protein transport out of the endoplasmic reticulum (ER). It re-glucosylates incompletely folded glycoproteins to monoglucosylated intermediates.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
The recognition motif of the glycoprotein-folding sensor enzyme UDP-Glc: glycoprotein glucosyltransferase
Totani K, et al.
Biochemistry, 48(13), 2933-2940 (2009)
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
