SAB4200326

Anti-LRP1B (C-terminal region) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• Synonym(s): Anti-LRP-DIT, Anti-LRPDIT, Anti-Low density lipoprotein receptor-related protein 1B
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~190 kDa (Rat); antigen ~200 kDa (Human)
• species reactivity: human, rat, mouse
• concentration: ~1.5 mg/mL
• technique(s): immunoprecipitation (IP): 5-10 μg using extracts of HEK-293T cells overexpressing human LRP1B.; indirect immunofluorescence: 1-2 μg/mL using HEK-293T cells overexpressing human LRP1B.; western blot: 1.5-3.0 μg/mL using extracts of rat brain (S1 fraction) and mouse brain (S1 fraction).
• UniProt accession no.: Q9NZR2
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... LRP1B(53353) ; mouse ... Lrp1b(94217) ; rat ... Lrp1b(311926)

Description

General description

LDL receptor-related protein 1B (LRP1B) belongs to the low-density lipoprotein (LDL) receptor gene family, including LDLR, LRPs (low density lipoprotein related proteins), megalin/GP330, VLDLR (very low density lipoprotein receptor) and ApoER2.

Immunogen

synthetic peptide corresponding to a sequence near the C-terminus of human LRP1B, conjugated to KLH. The corresponding sequence is identical in mouse LRP1B.

Application

Anti-LRP1B (C-terminal region) antibody produced in rabbit has been used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

Biochem/physiol Actions

LDL receptor-related protein 1B (LRP1B) is a candidate tumor suppressor gene, that is inactivated in several types of human malignancies, including non-small cell lung cancer (NSCLC) and plays an important role in tumorigenesis. It regulates the endocytic trafficking of the β-amyloid precursor protein (APP) and reduces the production of amyloid-β peptide (Ab) involved in the pathogenesis of Alzheimer′s disease. LRP1B regulates the degradation of the platelet derived growth factor-β receptor (PDGFR-β) and is implicated in the development of atherosclerosis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable