SAB4200308

Anti-Synaptotagmin 7 (C-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• Synonym(s): Anti-IPCA-7, Anti-PCANAP7, Anti-SYT-VII, Anti-SYT7
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~45 kDa
• species reactivity: human, rat, mouse
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• concentration: ~1.5 mg/mL
• technique(s): western blot: 2-4 μg/mL using mouse brain extracts (S1 fraction), rat brain extracts (S1 fraction) or HEK-293T cell lysates over expressing human synaptotagmin 7
• UniProt accession no.: O43581
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SYT7(9066) ; mouse ... Syt7(54525) ; rat ... Syt7(59267)

Description

General description

Synaptotagmin7 (SYT7) belongs to the synaptotagmin gene family. It codes for and encodes a single-pass 46-kDa transmembrane protein and is located on human chromosome11q12.2. Syt7 contains a single transmembrane domain, a variable linker sequence and C₂A and C₂B Ca²⁺-binding domains. It is ubiquitously expressed during development, but is later restricted to dividing cells, postmitotic neurons and neuroendocrine cells.

Immunogen

synthetic peptide corresponding to a sequence located near the C-terminus of human synaptotagmin 7 (Syt7), conjugated to KLH. The corresponding sequence is identical in rat and mouse Syt7.

Application

Anti-Synaptotagmin 7 (C-terminal) antibody produced in rabbit has been used in immunoblotting (~45 kDa).

Biochem/physiol Actions

Synaptotagmin7 (SYT7) helps to facilitate the calciumdependent modulation of membrane trafficking during synaptic transmission. It has been proposed to regulate different types of Ca²⁺ -dependent exocytosis. Syt7 has been proposed to play a key role in the regulation of Ca²⁺- dependent lysosome exocytosis. Knockout of Syt7 in mice results in impaired insulin secretion and glucose intolerance.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable