SAB4200264
Anti-Dystrobrevin-α (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
Synonym(s):
Anti-DRP3, Anti-DTN, Anti-DTNA, Anti-DYSTROPHIN-RELATED PROTEIN 3, Anti-LVNC1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~84 kDa
species reactivity
rat, mouse, human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 15-30 μg using rat brain extracts (S1 fraction).
western blot: 1.5-3.0 μg/mL using HEK-293T cell lysates or mouse brain extracts (S1 fraction).
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DTNA(1837)
mouse ... Dtna(13527)
rat ... Dtna(307548)
General description
Dystrobrevin-α (α-DB) gene is mapped to human chromosome 18q12.1. α-DB protein belongs to the dystrobrevin (DB) subfamily of the dystrophin family. α-DB is an extracellular component of the dystrophin-glycoprotein complex (DGC) that is located at the muscle sarcolemma. It forms a transmembrane link between the cytoskeleton and the basal lamina. In mammalian cells, the DB family includes two isoforms α-DB and β-DB encoded by different genes. In skeletal and cardiac muscle, alternative splicing of α-DB mRNA gives rise to a least five isoforms that differ in sequence and tissue distribution. α-DB is also abundantly expressed in developing neurons and in the adult central nervous system (CNS), sensory organs and various epithelia.
Specificity
Anti-Dystrobrevin-α (C-terminal) specifically recognizes human, rat and mouse dystrobrevin-α.
Immunogen
synthetic peptide corresponding to a sequence located at the C-terminus of human dystrobrevin-a (DTNA), conjugated to KLH. The corresponding sequence is identical in human DTNA isoforms 2 and 6, in mouse DTNA, and highly conserved in rat DTNA (88% sequence identity).
Application
Anti-Dystrobrevin-α (C-terminal) antibody produced in rabbit is suitable for immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Dystrobrevin-α (α-DB) is thought to be involved in the formation, maturation and stability of synapses and in the clustering of nicotinic acetylcholine receptors. Mutations in the dystrophin glycoprotein complex (DGC) are associated with congenital heart defects. Dystrobrevin (DB) is markedly reduced or absent in the sarcolemma of patients with Duchenne muscular dystrophy (DMD).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Anna Zlotina et al.
Molecular cytogenetics, 9, 18-18 (2016-02-20)
Ring chromosome 18 [r(18)] syndrome represents a relatively rare condition with a complex clinical picture including multiple congenital dysmorphia and varying degrees of mental retardation. The condition is cytogenetically characterized by a complete or mosaic form of ring chromosome 18
Melissa L J Rees et al.
Neuromuscular disorders : NMD, 17(2), 123-134 (2007-01-26)
The alpha- and beta-dystrobrevins belong to the family of dystrophin-related and dystrophin-associated proteins. As constituents of the dystrophin-associated protein complex, alpha-dystrobrevin was believed to have a role predominantly in muscles and beta-dystrobrevin in non-muscle tissues. Recent reports described novel localisations
Derek J Blake et al.
Physiological reviews, 82(2), 291-329 (2002-03-28)
The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations in the gene encoding dystrophin. There is currently no effective treatment for the disease; however, the complex molecular pathology of this disorder is now being unravelled. Dystrophin is located
Isabel Martinez-Pena y Valenzuela et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(43), 15586-15596 (2011-10-28)
α-Syntrophin (α-syn), a scaffold protein, links signaling molecules to the dystrophin-glycoprotein complex. Absence of α-syn from the DGC is known to lead to structurally aberrant neuromuscular junctions (NMJs) with few acetylcholine receptors (AChRs) clustered at synaptic sites. Using α-syn knock-out
T Haenggi et al.
Cellular and molecular life sciences : CMLS, 63(14), 1614-1631 (2006-05-20)
The dystrophin glycoprotein complex (DGC) is a multimeric protein assembly associated with either the X-linked cytoskeletal protein dystrophin or its autosomal homologue utrophin. In striated muscle cells, the DGC links the extracellular matrix to the actin cytoskeleton and mediates three
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