Contactin-2 (CNTN2),also known as TAG-1, axonin-1, Tax, astaxanthin (AXT), is an axonal glycoprotein, encoded by the gene mapped to human chromosome 1q32.1. The protein belongs to the neuronal cell adhesion molecules of the immunoglobulin superfamily (IgCAMs). Contactin-2/TAG-1 is predominantly expressed during early neural development. The protein contains six extracellular immunoglobulin-like domains and four fibronectin III-like domains.
Specificity
Anti-Contactin-2 (C-terminal) specifically recognizes human contactin-2.
Immunogen
synthetic peptide corresponding to a sequence located near the C-terminus of human contactin-2, conjugated to KLH. The corresponding sequence is highly conserved (89% sequence identity) in rat and mouse contactin-2.
Application
Anti-Contactin-2 (C-terminal) antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Contactin-2 (CNTN2) is involved in axonal formation and pathfinding. It also mediates axon-Schwann cell interactions and is localized in juxtaparanodal region. Mutation in the gene causes chronic inflammatory demyelinating polyneuropathy (CIDP) and Alzheimer′s disease (AD). Contactin-2 serves as a target for T cells and autoantibodies in multiple sclerosis (MS) patients. Contactin-2 has been suggested to be a functional ligand for amyloid precursor protein (APP). The interaction of CNTN2 with APP increases γ-secretase-mediated release of APP intracellular fragment (AICD), inducing a Fe65- dependent suppression of neurogenesis.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
