α 4 is a phosphoprotein that is expressed in a wide range of tissues, including pancreas, lymph node, thymus, kidney, leukocytes, fetal liver, heart, and brain. This phosporpotein associates with protein phosphatases 2A, 4, and 6 to regulate the rapamycin-sensitive pathway mediated by FRAP. α4 also binds to MID-1 and subsequently modulates PP2A function . Monoclonal Anti-α4 antibody is specific for human and mouse α4 (approx. 40 kDa).
Immunogen
mouse Alpha4 fusion protein. The corresponding sequence shares 80% homology with human Alpha4.
Application
Monoclonal Anti-α4 antibody is suitable for use in western blot (1-2 μg/mL using whole extracts of mouse 3T3 or human HeLa cells).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Biochemical and biophysical research communications, 247(3), 827-832 (1998-07-02)
Protein phosphatases participate in the regulation of a variety of cellular processes. Control of their enzymatic activity and specificity is made possible largely by an array of regulatory subunits. Novel serine/threonine phosphatases--PP4 and PP6 in human cells--have been discovered recently
Alpha4 is a regulatory subunit of the protein phosphatase family of enzymes and plays an essential role in regulating the catalytic subunit of PP2A (PP2Ac) within the rapamycin-sensitive signaling pathway. Alpha4 also interacts with MID1, a microtubule-associated ubiquitin E3 ligase
Lamin C2 (LMN C2) is a short product of the lamin a gene. It is a germ cell-specific lamin and has been extensively studied in male germ cells. In this study, we focussed on the expression and localization of LMN
To study the function of the B cell signal transduction molecule alpha 4 (IGBP1), we isolated a human alpha 4 (IGBP1) gene that has sequence similarity to the yeast protein (TAP42) involved in the rapamycin-sensitive signal transduction pathway. The human
Questions
Reviews
★★★★★ No rating value
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
