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SAB4200221

Sigma-Aldrich

Anti-GrpL/GADS antibody, Mouse monoclonal

clone UW40, purified from hybridoma cell culture

Synonym(s):

Anti-GRAP2, Anti-GRB2-related adaptor protein 2, Anti-GRB2-related protein with insert domain, Anti-GRB2L, Anti-GRBLG, Anti-GRBX, Anti-GRF40, Anti-GRID, Anti-GRPL, Anti-Growth factor receptor-bound protein 2-related adaptor protein 2, Anti-Hematopoietic cell-associated adapter protein GrpL, Anti-Mona, Anti-P38, GRB-2-like protein, Anti-RP3-370M22.1, Anti-SH3-SH2-SH3 adapter Mona

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About This Item

MDL number:
MFCD03455450
UNSPSC Code:
12352203
NACRES:
NA.44

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

UW40, monoclonal

form

buffered aqueous solution

mol wt

antigen ~41 kDa

species reactivity

human, mouse

concentration

~1.0 mg/mL

technique(s)

flow cytometry: suitable
immunoprecipitation (IP): suitable
western blot: 0.5-1.0 μg/mL using whole extracts of human Jurkat cells

isotype

IgG2a

UniProt accession no.

O75791

Storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GRAP2(9402)

General description

GrpL is a SH2- and SH3-domain containing adaptor protein that regulates tyrosine kinase signaling in leukocytes. This adaptor protein associates with SLP-76 and subsequently enhances NF-AT activation in T cells. GrpL also interacts with gab-1 . Monoclonal Anti-GrpL/GADS antibody is specific for human and mouse GrpL.

Immunogen

fusion protein expressing human GrpL.

Application

Monoclonal Anti-GrpL/GADS antibody is suitable for use in western blot (0.5-1.0 μg/mL using whole extracts of human Jurkat cells), immunoprecipitation and flow cytometry.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000141289
0000137217
080M4835

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C L Law et al.
The Journal of experimental medicine, 189(8), 1243-1253 (1999-04-20)
Propagation of signals from the T cell antigen receptor (TCR) involves a number of adaptor molecules. SH2 domain-containing protein 76 (SLP-76) interacts with the guanine nucleotide exchange factor Vav to activate the nuclear factor of activated cells (NF-AT), and its
M Qiu et al.
Biochemical and biophysical research communications, 253(2), 443-447 (1999-01-08)
The SH2- and SH3-containing adaptor molecules serve to recruit cytosolic signal-transducing molecules to the activated receptor tyrosine kinases. In this study, we report the molecular cloning of a novel adaptor-like protein, Grap-2 (Grb-2 related adaptor protein 2), using the multisubstrate

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