SAB4200169
Anti-PPM1M (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
Synonym(s):
Anti-PP2C-ETA, Anti-PP2CE, Anti-Protein phosphatase 2C, ETA isoform, Anti-Protein phosphatase, magnesium-dependent, 1M
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.44
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~33 kDa
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 2.5-5.0 μg using lysates of HEK-293T cells over-expressing human PPM1M
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PPM1M(132160)
General description
Protein phosphatase, Mg2+/Mn2+ dependent 1M (PPM1M), also known as protein phosphatase 2C isoform η (PP2C-η or PP2CE) is a novel member of the protein serine/threonine phosphatase 2C family. At least 14 distinct PP2C family members have been identified in mammalian cells, all sharing six conserved structural motifs. PPM1M is ubiquitously expressed and localizes in the nucleus of cells. The PPM1M gene is mapped to human chromosome 3p21.2.
Specificity
Anti-PPM1M (C-terminal) recognizes human PPM1M.
Application
Anti-PPM1M (C-terminal) antibody is suitable for use in immunoprecipitation (2.5-5.0 μg) using lysates of HEK-293T cells over-expressing human PPM1M. The product may also be used for western blot (approx. 33 kDa).
Anti-PPM1M (C-terminal) antibody produced in rabbit is suitable for immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Decreased PPM1M gene expression is associated with the inhibition of Herpes simplex virus 1 (HSV-1) infection.
Dephosphorylation of inhibitor of nuclear factor κ B kinase subunit β (IKKβ) by protein phosphatase, Mg2+/Mn2+ dependent 1M (PPM1M) inhibits interleukin-1 (IL-1)-nuclear factor κB (NF-κB) mediated signal transduction. Thus, PPM1M may have implications in regulating pro-inflammatory responses.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Storage and Stability
Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yue Xu et al.
Medical science monitor : international medical journal of experimental and clinical research, 26, e922710-e922710 (2020-05-26)
BACKGROUND Keratitis is a complex condition in humans and is the second most common cause of legal blindness worldwide. MATERIAL AND METHODS To reveal the genomic loci underlying keratitis, we performed functional annotations of SNP-based and gene-based genome-wide association studies
Shinri Tamura et al.
Cancer science, 97(7), 563-567 (2006-07-11)
Although unlimited proliferation of cancer cells is supported by multiple signaling pathways involved in the regulation of proliferation, survival, and apoptosis, the molecular mechanisms coordinating these different pathways to promote the proliferation and survival of cancer cells have remained unclear.
Ken-ichiro Komaki et al.
Biochimica et biophysica acta, 1630(2-3), 130-137 (2003-12-05)
We have cloned a novel member of the mouse protein phosphatase 2C family, PP2Ceta. Sequence analysis suggests that PP2Ceta, PP2Czeta and NERPP-2C constitute a unique subgroup of the PP2C family. PP2Ceta had extremely low activity against alpha-casein compared with PP2Calpha
Takeaki Henmi et al.
The Biochemical journal, 423(1), 71-78 (2009-07-15)
IL-1 (interleukin-1) is a pro-inflammatory cytokine that has a variety of effects during the process of inflammation. Stimulating cells with IL-1 initiates a signalling cascade that includes the activation of NF-kappaB (nuclear factor kappaB), and subsequently induces a variety of
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