Importin 7 is also known as IPO7 and IMP7. It is located on the human chromosome at 12q13.11.
Immunogen
synthetic peptide corresponding to amino acids 2-16 of human Importin 7 conjugated to KLH. The corresponding sequence is identical in mouse and rat Importin 7.
application
Anti-Importin 7 (N-terminal) antibody has been used in
immunoblotting
immunoprecipitation
western blotting
Biochem/physiol Actions
Importins mediate the nuclear import, for a very diverse set of protein or RNA cargoes. Importin 7 has been identified as an importin for ribosomal protein L23a (rpL23a), histone H1, HIV (Human immunodeficiency virus) reverse transcriptase complex and the zinc finger protein (EZI).
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Import of proteins into the nucleus proceeds through nuclear pore complexes and is largely mediated by nuclear transport receptors of the importin beta family that use direct RanGTP-binding to regulate the interaction with their cargoes. We investigated nuclear import of
Cell and tissue research, 322(1), 159-165 (2005-04-23)
Testicular cancer is the most common malignancy among men in the reproductive age and the incidence is increasing, probably caused by environmental factors. Most testicular cancers are testicular germ cell tumours and all originate from a carcinoma in situ (CIS)
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