In human cells, there are more than 20 members of the importins/exportins family. Importin 7 (also known as IPO7, RANBP7 and IMP7) has been identified as an importin for ribosomal protein L23a (rpL23a), histone H1, human immunodeficiency virus (HIV) reverse transcriptase complex and the zinc finger protein, EZI.
Immunogen
synthetic peptide corresponding to amino acids 943-957 of human Importin 7
Application
Anti-Importin 7 (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Nucleocytoplasmic transport of proteins and RNAs is mediated through nuclear pore complexes (NPCs) and by karyopherins nuclear transport receptors (importins/exportins). Importins mediate either the nuclear import of a very diverse set of protein or RNA cargoes. The function of importins areregulated by the Ran G protein., Ran G protein stimulates the release of cargo from importins. Importins are implicated in anti-aggregation activity of highly basic cargo like histones and ribosomal proteins and in preventing their undesired interactions with other cellular components.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
International journal of cancer, 132(4), 775-784 (2012-07-21)
In primary prostate cancer (PCa), a major cause of cancer-related death in men, the expression of various microRNAs (miRNAs) is deregulated. We previously detected several miRNAs, for example, miR-24 and miR-22, as significantly downregulated in PCa (Szczyrba et al., Mol
Structural biology of nucleocytoplasmic transport
Cook A, et al.
Annual Review of Biochemistry, 76(3), 647-671 (2007)
Importins fulfil a dual function as nuclear import receptors and cytoplasmic chaperones for exposed basic domains
Jakel S, et al.
The Embo Journal, 21(3), 377-386 (2002)
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