FIP200 (focal adhesion kinase family interacting protein of 200 kDa), also known as RB1CC1 (retinoblastoma 1-inducible coiled-coil 1), is a multifunctional protein. It is mainly localized in the cytoplasm. The FIP200 gene is mapped to human chromosome 8q11.23.
Specificity
Anti-FIP200 (C-terminal) recognizes human FIP200.
Application
Anti-FIP200 (C-terminal) antibody produced in rabbit has been used in immunoblotting.[1]
Biochem/physiol Actions
Focal adhesion kinase family interacting protein of 200 kDa (FIP200) interacts with UNC-51-like kinase (ULK 1) and is essential for autophagy. It also interacts with Pyk2 (proline-rich tyrosine kinase 2), FAK (focal adhesion kinase), TSC1 (TSC complex subunit 1), p53, apoptosis signal-regulating kinase 1 (ASK1) and TRAF2 (TNF receptor associated factor 2) and regulates cell growth, cell proliferation, cell survival, cell adhesion and cell migration. Deficiency in FIP200 is associated with embryonic death and cancer development.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). C9orf72 encodes two C9orf72 protein isoforms of unclear function. Reduced levels of C9orf72 expression have been reported
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