SAB4200128

Anti-DYX1C1 (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

• Synonym(s): Anti-DYX1, Anti-DYXC1, Anti-Dyslexia susceptibility 1 candidate 1, Anti-EKN1, Anti-RD
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~48 kDa
• species reactivity: human
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• concentration: ~1.5 mg/mL
• technique(s): western blot: 1-2 μg/mL using lysates of HEK-293T cells overexpressing human DYX1C1
• shipped in: dry ice
• Storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... DYX1C1(161582)

Description

General description

Anti-DYX1C1 (N-terminal) is produced in rabbit using as the immunogen a synthetic peptide corresponding to a sequence at the N-terminal of human DYX1C1, conjugated to KLH. DYX1C1 is expressed in brain and the protein resides in the nucleus.

DYX1C1/dynein axonemal assembly factor 4 (DNAAF4) gene with 10 exons, extending over a length of ~78 kb on genomic DNA, is mapped to human chromosome 15q21.3. DYX1C1 contains a nuclear tetratricopeptide repeat domain.

Application

Anti-DYX1C1 (N-terminal) antibody produced in rabbit has been used in immunoblotting.

Anti-DYX1C1 (N-terminal) antibody produced in rabbit has been used in immunofluorescence studies.

Biochem/physiol Actions

DYX1C1 has been recently implicated as a cancer biomarker in colorectal cancer.

DYX1C1/dynein axonemal assembly factor 4 (DNAAF4) plays a vital role in neuronal migration and regulation of estrogen receptor signaling. Mutation in the gene increases the risk of susceptibility to developmental dyslexia (DD). Variations in the gene is also associated with the deficits in reading, orthographic skills and spelling.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable