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SAB4200127

Sigma-Aldrich

Anti-DYX1C1 antibody produced in rabbit

enhanced validation

~1.5 mg/mL, affinity isolated antibody

Synonym(s):

Anti-DYX1, Anti-DYXC1, Anti-Dyslexia susceptibility 1 candidate 1, Anti-EKN1, Anti-FLJ37882, Anti-MGC70618, Anti-RD

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~48 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.5 mg/mL

technique(s)

western blot: 1-2 μg/mL using HEK-293T cell lysate expressing human DYX1C1

shipped in

dry ice

Storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... DYX1C1(161582)
mouse ... Dyx1c1(67685)
rat ... Dyx1c1(363096)

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General description

The dyslexia susceptibility 1 candidate 1 (DYX1C1) gene is located near the DYX1 locus in the human chromosome 15q21. The encoded protein contains three tetratricopeptide repeat (TPR) domains. DYX1C1 is expressed in several tissues, including the brain, lungs and kidney. The protein resides in the nucleus of the cortical neurons and glial cells.

Specificity

Anti-DYX1C1 specifically recognizes human DYX1C1.

Application

Anti-DYX1C1 antibody produced in rabbit is suitable for immunoblotting.

Biochem/physiol Actions

The dyslexia susceptibility 1 candidate 1 (DYX1C1) gene is identified as a candidate gene implicated in dyslexia due to chromosomal translocations. The encoded protein is involved in neuronal migration and other developmental processes. It also functions as protein interaction modules. Knockdown of the gene DYX1C1 by RNA interference (RNAi) in rats causes a deficit in neuronal migration in the developing neocortex, auditory processing, and spatial learning, supporting the role of DYX1C1 in dyslexia. The protein is known to be implicated as a cancer biomarker in colorectal cancer.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing is not recommended. Storage in “frost-free” freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
040M4762

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Albert M Galaburda et al.
Nature neuroscience, 9(10), 1213-1217 (2006-09-27)
All four genes thus far linked to developmental dyslexia participate in brain development, and abnormalities in brain development are increasingly reported in dyslexia. Comparable abnormalities induced in young rodent brains cause auditory and cognitive deficits, underscoring the potential relevance of
Steven W Threlkeld et al.
Brain research bulletin, 71(5), 508-514 (2007-01-30)
Developmental malformations of cortex have been shown to co-occur with language, learning, and other cognitive deficits in humans. Rodent models have repeatedly shown that animals with such developmental malformations have deficits related to auditory processing and learning. More specifically, freeze-lesion
Mikko Taipale et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(20), 11553-11558 (2003-09-05)
Approximately 3-10% of people have specific difficulties in reading, despite adequate intelligence, education, and social environment. We report here the characterization of a gene, DYX1C1 near the DYX1 locus in chromosome 15q21, that is disrupted by a translocation t(2;15)(q11;q21) segregating
Yun-Ji Kim et al.
Journal of cancer research and clinical oncology, 135(2), 265-270 (2008-07-12)
DYX1C1 has three alternatively spliced transcripts. Therefore, we expect that alternative transcripts of DYX1C1 are used as a biomarker to detect specific cancer. RT-PCR analysis is conducted in order to detect expression of the DYX1C1 gene and the PCR products

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