SAB4200077

Anti-Coronin-1C (C-terminal)

~1.5 mg/mL, affinity isolated antibody

• Synonym(s): Anti-CLABP, Anti-CLIPINA (Coronin-like protein A), Anti-CORO1A, Anti-HCORO1, Anti-TACO (Tryptophane aspartate-containing goat protein ), Anti-p57
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~57 kDa
• species reactivity: rat, mouse, human
• packaging: antibody small pack of 25 μL
• concentration: ~1.5 mg/mL
• technique(s): western blot: 1.5-3.0 μg/mL using Jurkat cell lysates, or lysates of mouse brain (S1 fraction) or rat spleen (S1 fraction)
• UniProt accession no.: P31146
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CORO1A(11151)

Description

General description

Coronin 1C (CORO1C) is encoded by the gene mapped to human chromosome 12q24.1. The encoded protein belongs to coronin-like family of proteins. CORO1C consists of 474 amino acids and is ubiquitously expressed in human tissues. CORO1C contains conserved five WD repeats in its N-terminal end and a coiled-coil motif in its C-terminal end.The protein is mainly present at the sites of active actin dynamics including lamellipodia and membrane ruffles.

Specificity

Anti-Coronin-1A (C-terminal) specifically recognizes human, mouse, and rat coronin-1A.

Biochem/physiol Actions

Coronin 1C (CORO1C) plays a vital role in cytokinesis, motility and signal transduction. It is also implicated in regulation of various cellular processes such as cell proliferation, migration, invadopodia formation and invasion in glioblastoma cells. CORO1C acts as a predictive biomarker for hepatocellular carcinoma (HCC) invasive behavior. The encoded protein negatively regulates cell-matrix adhesion and intestinal epithelial cells (IECs) migration via FAK-mediated signaling.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze in working aliquots at –20 °C. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable