XTP3-transactivated gene B precursor (XTP3-B), also known as Erlectin is an ER-resident lectin. XTP3-B contains two mannose 6-phosphate receptor homology (MRH) domains in its sequence. The XTP3-B gene is mapped to human chromosome 2p16.2.
Application
Anti-XTP3-B antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
XTP3-transactivated gene B precursor (XTP3-B), plays a role in endoplasmic-reticulum-associated protein degradation (ERAD) selection and targeting processes. Human XTP3-B associates with the SEL1L/HRD1 ubiquitin ligase complex in the ER membrane and with the ER chaperone BiP, forming an ER quality control scaffold complex. This large complex is involved in identifying and sorting of misfolded glycoproteins and non-glycosylated proteins prior to retrotranslocation into the cytoplasm for degradation.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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The Journal of biological chemistry, 281(18), 12986-12993 (2006-03-15)
Kremen1 and 2 (Krm1/2) are coreceptors for Dickkopf1 (Dkk1), an antagonist of Wnt/beta-catenin signaling, and play a role in head induction during early Xenopus development. In a proteomic approach we identified Erlectin, a novel protein that interacts with Krm2. Erlectin
Terminally misfolded or unassembled proteins in the early secretory pathway are degraded by a ubiquitin- and proteasome-dependent process known as ER-associated degradation (ERAD). How substrates of this pathway are recognized within the ER and delivered to the cytoplasmic ubiquitin-conjugating machinery
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