SAB4200038

Anti-SORBS2 (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-ARGBP2, Anti-Arg binding protein 2, Anti-Arg/Abl-interacting protein 2, Anti-Sorbin and SH3 domain containing 2
• UNSPSC Code: 12352203
• NACRES: NA.44

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~85 kDa
• species reactivity: human
• packaging: antibody small pack of 25 μL
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• concentration: ~1.5 mg/mL
• technique(s): indirect immunofluorescence: 20-40 μg/mL using HeLa cells; western blot: 0.2-0.4 μg/mL using HEK-293T cell lysates expressing human SORBS2
• UniProt accession no.: O94875
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... SORBS2(8470)

Description

General description

SORBS2 (also known as ArgBP2), is an Arg/Abl (proto-oncogene 1, non-receptor tyrosine kinase)-binding protein, that contains an N-terminal sorbin homology (SoHo) domain which interacts with lipid raft proteins, three C-terminal SH3 domains, a Ser/Thr-rich domain, and several potential Abl phosphorylation sites. SORBS2 associates with and is a substrate of Arg and v-Abl. The human SORBS2 gene encodes multiple transcripts that yield different isoforms. SORBS2 is ubiquitously expressed in human tissues and predominant in heart and epithelial cells. SORBS2 is also found in stress fibers and in the nucleus. In cardiac muscle cells, SORBS2 is in the Z-disks of sarcomeres.

Application

Anti-SORBS2 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

Sorbin and SH3 domain containing 2 (SORBS2) might function as an adapter protein to assemble signaling complexes in stress fibers and is a potential link between Abl kinases and the actin cytoskeleton.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• flash_point_f: Not applicable
• flash_point_c: Not applicable