The solute carrier family 9 member A1 (SLC9A1) gene is mapped to human chromosome 1p36.11. The encoded protein is widely expressed in many tissues and is localized to the plasma membrane. SLC9A1 is the only isoform found in mammalian cardiomyocytes. This gene encodes a 815 amino acid protein containing 12 transmembrane spanning domain and a cytoplasmic domain with many regulatory sites.
Application
Anti-SLC9A1 antibody produced in rabbit has been used in western blotting.
Biochem/physiol Actions
Solute carrier family 9 member A1 (SLC9A1) mediates the electroneutral exchange of Na+-H+ in response to intracellular acidosis. It drives extracellular Na+ uptake in exchange for intracellular H+. SLC9A1 maintains the pH and cell volume regulation of vertebrate cells. It is specifically inhibited by the diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters and cell shrinkage.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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The Journal of biological chemistry, 291(47), 24787-24799 (2016-10-14)
Hypotonic stress decreased claudin-1 and -2 expression levels in renal tubular epithelial HK-2 and Madin-Darby canine kidney cells. Here, we examined the regulatory mechanism involved in this decrease. The hypotonicity-induced decrease in claudin expression was inhibited by the following: SB202190
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