SAB4200014
Anti-TRIP6 antibody, Mouse monoclonal
clone TRP(N)-12, purified from hybridoma cell culture
Synonym(s):
Anti-MGC10556, Anti-MGC10558, Anti-MGC29959, Anti-MGC3837, Anti-MGC4423, Anti-OIP1, Anti-Thyroid hormone receptor interactor 6, Anti-ZRP1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
TRP(N)-12, monoclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
human, bovine
concentration
~1.0 mg/mL
technique(s)
western blot: 0.5-1.0 μg/mL using whole extract of human HeLa cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TRIP6(7205)
General description
Monoclonal Anti-TRIP6 (mouse IgG1 isotype) is derived from the hybridoma TRP(N)-12 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Thyroid hormone receptor interactor 6 (TRIP6) is a member of the zyxin family. The TRIP6 gene encodes a protein with three Lin11, Isl-1, Mec-3 (LIM) zinc-binding domains at its carboxy- terminus, a proline-rich region and nuclear export signals at its aminoterminus. TRIP6 transcripts are strongly detected in highly vascularized tissues such as lungs, placenta, heart, and kidney. This protein localizes to focal adhesion sites and along actin stress fibers. The TRIP6 gene is mapped on the human chromosome at 7q22.1.
Specificity
Monoclonal Anti-TRIP6 recognizes human and bovine TRIP6.
Application
Anti-TRIP6 antibody, Mouse monoclonal may be used in immunoblotting.
Biochem/physiol Actions
Thyroid hormone receptor interactor 6 (TRIP6) is recruited to the plasma membrane in a lysophosphatidic acid (LPA)-dependent manner and it also regulates LPA-induced cell migration. This protein is postulated to serve as a docking site for the assembly of multimeric protein complexes involved in regulating cytoskeleton assembly and cell motility.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Storage and Stability
Store at –20 °C. For continuous use, the product may be stored at 2–8 °C for up to one month. For extended storage, freeze at –20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Jun Xu et al.
The Journal of biological chemistry, 279(11), 10459-10468 (2003-12-23)
Lysophosphatidic acid (LPA) induces actin rearrangement, focal adhesion assembly, and cell migration through the activation of small G protein Rho and its downstream effectors. These diverse cellular responses are mediated by its associated G protein-coupled receptors. However, the mechanisms and
Yuan Wang et al.
Biochimica et biophysica acta, 1593(2-3), 115-120 (2003-02-13)
Zyxin and paxillin are the prototypes of two related subfamilies of LIM domain proteins that are localized primarily at focal adhesion plaques. However, recent work has shown that zyxin/paxillin family proteins also shuttle through the nucleus. These proteins may enter
Jie Huang et al.
Blood, 120(24), 4873-4881 (2012-09-20)
We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects
Jinseong Yi et al.
The Journal of biological chemistry, 277(11), 9580-9589 (2002-01-10)
Integrin binding to extracellular matrix proteins induces formation of signaling complexes at focal adhesions. Zyxin co-localizes with integrins at sites of cell-substratum adhesion and is postulated to serve as a docking site for the assembly of multimeric protein complexes involved
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