Kindlin-3 is a member of the kindlin family of focal adhesion proteins. The kindlin family consists of three members in vertebrates, kindlin-1, kindlin-2 and kindlin-3 that share high sequence homology and a common structure containing a C-terminal 4.1R, ezrin, radixin, moesin (FERM) domain and a pleckstrin-homology domain. Kindlin-1 and kindlin-2 are widely expressed, kindlin-3 is preferentially expressed in hematopoietic cells, mainly in megakaryocytes and platelets.
Application
Anti-Kindlin-3 antibody produced in rabbit has been used in western blotting and immunoblotting.
Biochem/physiol Actions
Kindlin-3 is required for integrin-mediated leukocyte adhesion to endothelial cells. Mutations in kindlin-3 cause leukocyte adhesion deficiency-III. Kindlin-1, kindlin-2 and kindlin-3 are essential for the regulation of integrin activation by binding the tails of integrin-β subunits. Loss of kindlins results in severe defects in integrin signaling, cell-ECM adhesion and cytoskeletal organization. Deficiency of kindlin-1 results in kindler syndrome, kindlin-2 results in early embryonic lethality due to cardiac developmental problems, and kindlin-3 results in postnatal lethality.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
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