The exportin 5 (XPO5) gene is mapped to human chromosome 6p21.1 and belongs to the karyopherin family. Exportin 5 (also known as XPO5, Exp5, Ran-binding protein 21) is identified as a nuclear receptor for interleukin enhancer binding factor 3 (ILF3), a double-stranded RNA binding protein (dsRBP) and for several other dsRBPs.
Application
Anti-Exportin 5 (C-terminal) antibody produced in rabbit has been used in western blotting and immunofluorescence.
Biochem/physiol Actions
Exportin 5 (XPO5) plays an important role in microRNA (miRNA) cellular processing for the production of mature miRNAs. The encoded protein It transports miRNA from the nucleus to the cytoplasm in RNA-guanosine triphosphate (GTP) dependent manner. Impaired XPO5 gene expression is observed in many types of cancer. Exportin 5 can also export RNA such as viral hairpin RNAs, some tRNAs and pre-microRNAs, which are likely to be its major endogenous cellular RNA cargos.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Genes to cells : devoted to molecular & cellular mechanisms, 20(4), 281-291 (2015-02-07)
The signal recognition particle is a ribonucleoprotein complex that is essential for the translocation of nascent proteins into the endoplasmic reticulum. It has been shown that the RNA component (SRP RNA) is exported from the nucleus by CRM1 in the
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