Skip to Content
MilliporeSigma
All Photos(3)

Key Documents

SAB4100225

Sigma-Aldrich

Monoclonal Anti-POLR2E antibody produced in mouse

clone POLR2E-B178, culture supernatant

Synonym(s):

AntiPolymerase (RNA) II (DNA directed) polypeptide E, 25kDa, AntiRPABC1, AntiRPB5, AntiXAP4, AntihRPB25, AntihsRPB5

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

POLR2E-B178, monoclonal

form

aqueous solution

mol wt

antigen predicted mol wt 24.4 kDa

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG2a

UniProt accession no.

P19388

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... POLR2E(5434)

General description

RNA polymerase II subunit E (POLR2E) is also known as RPB5. It is a subunit of eukaryotic RNA polymerase II. This subunit is also shared by RNA polymerases I and III. The gene encoding POLR2E is localized on human chromosome 19p13.3.

Immunogen

POLR2E purified recombinant protein

Biochem/physiol Actions

RNA polymerase II subunit E (POLR2E) is a target for transcriptional modulation in signal transduction. It binds to transcription partners of RNA polymerase II and modulates transcription and gene expression. POLR2E also associates with hepatitis B virus X protein (HBx), which is known to have a role in the progression of hepatocellular carcinoma.

Physical form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Direct interaction between the subunit RAP30 of transcription factor IIF (TFIIF) and RNA polymerase subunit 5, which contributes to the association between TFIIF and RNA polymerase II.
Wei W
The Journal of Biological Chemistry (2001)
RPB5-mediating protein is required for the proliferation of hepatocellular carcinoma cells.
Yang H
The Journal of Biological Chemistry (2011)
Crystallization and preliminary X-ray analysis of the RPB5 subunit of human RNA polymerase II.
Ye X
Acta Crystallographica Section F, Structural Biology and Crystallization Communications (2011)
Use of bovine EST data and human genomic sequences to map 100
gene-specific bovine markers
Roger T Stone
Mammalian Genome (2002)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service