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Key Documents

SAB4100217

Sigma-Aldrich

Monoclonal Anti-PANK2 antibody produced in mouse

clone PANK2-A169, culture supernatant

Synonym(s):

AntiC20orf48, AntiHARP, AntiHSS, AntiHallervorden-Spatz syndrome, AntiNBIA1, AntiOTTHUMP00000030143, AntiOTTHUMP00000030148, AntiPKAN, AntiPantothenate kinase 2, AntiPantothenic acid kinase

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

PANK2-A169, monoclonal

form

aqueous solution

mol wt

antigen predicted mol wt 59.1 kDa

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG2a

UniProt accession no.

Q9BZ23

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... PANK2(80025)

General description

pantothenate kinase 2 (PANK2) gene is mapped to human chromosome 20p13-p12.3.[1][2] The gene codes for a mitochondrial protein PANK2.[2]

Immunogen

PANK2 purified recombinant protein

Biochem/physiol Actions

PANK2 acts as a key regulatory enzyme in coenzyme A biosynthesis.[3] Mutation in the gene is associated with the development of neurodegeneration with brain iron accumulation (NBIA).[2][1]

Physical form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Genotypic and phenotypic spectrum of PANK2 mutations in patients with neurodegeneration with brain iron accumulation
Hartig MB, et al.
Annals of Neurology, 59, 248-256 (2006)
PANK2 and C19orf12 mutations are common causes of neurodegeneration with brain iron accumulation
Dezfouli MA, et al.
Movement Disorders, 28, 228-232 (2013)
The Eye-of-the-Tiger Sign Is Not Pathognomonic of the PANK2 Mutation
Kumar N, et al.
Archives of Neurology, 63, 292-292 (2006)

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