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SAB4100064

Sigma-Aldrich

Monoclonal Anti-IDH1 antibody produced in mouse

clone IDH1-A36, culture supernatant

Synonym(s):

Anti-IDH, Anti-IDP, Anti-IDPC, Anti-Isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), Anti-NADP+-specific ICDH, Anti-NADP-dependent isocitrate dehydrogenase, cytosolic, Anti-NADP-dependent isocitrate dehydrogenase, peroxisomal, Anti-Oxalosuccinate decarboxylase, Anti-PICD

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

IDH1-A36, monoclonal

form

aqueous solution

mol wt

antigen predicted mol wt 46.7 kDa

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG1

UniProt accession no.

O75874

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IDH1(3417)

General description

Isocitrate dehydrogenase 1 (IDH1) is encoded by the gene mapped to human chromosome 2q34. It is a member of the isocitrate dehydrogenase enzymes family. IDH1 is mainly found in cytoplasm and peroxisomes.

Immunogen

IDH1 purified recombinant protein

Biochem/physiol Actions

Isocitrate dehydrogenase 1 (IDH1) acts as a regulator of cytoplasmic and peroxisomal lipid metabolism in various tissues. It catalyzes the conversion of isocitrate to α-ketoglutarate, which is a key cofactor for 2-OG-dependent dioxygenases. IDH1 facilitates various cellular processes such as adaptation to hypoxia, histone demethylation and DNA modification. It is also involved in the synthesis of plasmalogen lipids in peroxisomes. Somatic mutation of the gene is associated with the development of gliomas and acute myeloid leukaemia (AML).

Physical form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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IDH1, lipid metabolism and cancer: Shedding new light on old ideas
Bogdanovic E
Biochim. Biophys. Acta Gen. Subj., 1850(9), 1781-1785 (2015)
IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours
Amary MF, et al.
The Journal of Pathology, 224(3), 334-343 (2011)
IDH1/2 mutation detection in gliomas
Arita H, et al.
Brain Tumor Pathology, 32(2), 79-89 (2015)
M Udugama et al.
Nature communications, 12(1), 2584-2584 (2021-05-12)
Alternative Lengthening of Telomeres (ALT) is a telomere maintenance pathway utilised in 15% of cancers. ALT cancers are strongly associated with inactivating mutations in ATRX; yet loss of ATRX alone is insufficient to trigger ALT, suggesting that additional cooperating factors
Julie-Aurore Losman et al.
Science (New York, N.Y.), 339(6127), 1621-1625 (2013-02-09)
Mutations in IDH1 and IDH2, the genes coding for isocitrate dehydrogenases 1 and 2, are common in several human cancers, including leukemias, and result in overproduction of the (R)-enantiomer of 2-hydroxyglutarate [(R)-2HG]. Elucidation of the role of IDH mutations and

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