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SAB4100060

Sigma-Aldrich

Monoclonal Anti-RND1 antibody produced in mouse

clone RND1-A76, culture supernatant

Synonym(s):

Anti-ARHS, Anti-GTP-binding protein RHO6, Anti-RHO6, Anti-RHOS, Anti-Ras homolog gene family, member S, Anti-Rho family GTPase 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

RND1-A76, monoclonal

form

aqueous solution

mol wt

antigen predicted mol wt 25.9 kDa

species reactivity

human

technique(s)

western blot: suitable

isotype

IgG1

UniProt accession no.

Q92730

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RND1(27289)

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General description

RND1, a Rho GTPase, belongs to the family Rnd. The gene is located on human chromosome 12q13.12.

Immunogen

RND1 purified recombinant protein

Biochem/physiol Actions

Rho family GTPase 1 (RND1) regulates actin cytoskeleton in several cell types. It is implicated in the Sema3E/plexin-D1-induced inhibition of axon outgrowth in cortical neurons. RND1 plays an important role in plexin signaling. It modulates the dynamics of cell growth and survival. Dysregulation of RND1 is associated with tumorigenesis.

Physical form

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
031M2836

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RND1 is up-regulated in esophageal squamous cell carcinoma and promotes the growth and migration of cancer cells
Xiang G, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(1), 773-779 (2016)
Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation
Oinuma I, et al.
Molecular Biology of the Cell, 23(8), 1593-1604 (2012)
Structural basis of Rnd1 binding to plexin Rho GTPase binding domains (RBDs)
Wang H, et al.
The Journal of Biological Chemistry, 286(29), 26093-26106 (2011)
David Rizzo et al.
American journal of hematology, 88(9), 747-753 (2013-06-05)
It has recently been suggested that the percentage of smudge cells on blood smears from patients with chronic lymphocytic leukemia (CLL) could predict overall survival. However, smudge cells are a cytological artifact influenced by multiple physical factors not related to

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