IL-37 (interleukin 37) is an anti-inflammatory cytokine and is also termed as IL-1 family member 7 (IL-1F7). IL-37 belongs to the IL-1 cytokine family. This protein is expressed in blood monocytes, endothelial cells, adipocytes and epithelial cells. IL-37 is located on human chromosome 2q12.
Immunogen
Antibody was raised against a 17 amino acid peptide near the amino terminus of human IL-37.
Biochem/physiol Actions
IL-37 (interleukin 37) acts as a suppressor for innate immunity and acquired immunity. IL-37 participates in the immunosuppressive property of human CD4+CD25+ regulatory T cells. It represses the synthesis of several pro-inflammatory cytokines like IL-1α, IL-1β, IL-6, IL-12, granulocyte colony-stimulating factor (G-SCF), granulocyte-macrophage colony-stimulating factor (GM-CSF) and TNF-α (tumor necrosis factor alpha). It plays an important role in adaptive immunity.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Linkage
The action of this antibody can be blocked using blocking peptide SBP3500952.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodim azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Interleukin-1 as a Key Factor in the Development of Inflammatory Diseases.
Farivar S, et al.
Archives of Pediatric Infectious Diseases, 2(4), e18177-e18177 (2014)
Association between interleukin 37 (rs3811047) polymorphism and multiple autoimmune diseases in a Chinese population: A PRISMA-compliant meta-analysis.
Lin XY, et al.
Medicine, 97(15), e0386-e0386 (2018)
The interleukin-1 family: back to the future.
Garlanda C, et al.
Immunity, 39(6), 1003-1018 (2013)
Polymorphism of IL37 gene as a protective factor for autoimmune thyroid disease.
Yan N, et al.
Journal of Molecular Endocrinology, 55(3), 209-218 (2015)
Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis.
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