SAB3500780
Anti-CASKIN1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
predicted mol wt 157 kDa
species reactivity
human
technique(s)
ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CASKIN1(57524)
General description
CASK (Calcium/calmodulin-dependent serine protein kinase) interacting protein 1 (CASKIN1) is expressed in the neuronal cells. The N terminal region of Caskin1 have six ankyrin repeats, two sterile α motifs (SAM domains) and a single SH3 domain. The C-terminal region possesses a long proline-rich region. In human chromosome, the gene CASKIN1 is localized on 16p13.3.
Biochem/physiol Actions
CASK interacting protein 1 (CASKIN1) is a scaffold protein involved in synapses. Caskin1 interacts with Calcium/calmodulin-dependent serine protein kinase (Cask) in the CASK interaction domain (CID) adjacent to SAM domain. Caskin1 also interacts with Nck (non-catalytic region of tyrosine kinase adaptor protein 1)/Dock (dedicator of cytokinesis), neurexin2, synaptotagmin, and septin4. Caskin1 interacts with EphB1 (ephrinB ligands) through Nck adapter protein. The interaction phosphorylates the tyrosine residue in the SH3 domain and causes changes in the SH3 domain. Caskin1 forms a tripartite complex with Cask/caskin1/velis. Caskin1 competes with Munc-interacting protein 1 (Mint1) to form the tripartite complex. The tripartite complex binds to the cytoplasmic tail of neurexin, which is enriched in the presynaptic sites.
Features and Benefits
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Linkage
The action of this antibody can be blocked using blocking peptide SBP3500780.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Description
Pricing
Storage Class
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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The role of neuronal complexes in human X-linked brain diseases
Laumonnier F, et al.
American Journal of Human Genetics, 80(2), 205-220 (2007)
Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK
Stafford RL, et al.
Structure, 19(12), 1826-1836 (2011)
The molecular basis of the Caskin1 and Mint1 interaction with CASK
Stafford RL, et al.
Journal of Molecular Biology, 412(1), 3-13 (2011)
Szabolcs Pesti et al.
Cell communication and signaling : CCS, 10(1), 36-36 (2012-11-28)
Scaffold proteins have an important role in the regulation of signal propagation. These proteins do not possess any enzymatic activity but can contribute to the formation of multiprotein complexes. Although scaffold proteins are present in all cell types, the nervous
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