SAB3500661
Anti-VKORC1 antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
mol wt
18 kDa
species reactivity
mouse, human
concentration
1 mg/mL
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... VKORC1(79001)
General description
Vitamin K epoxide reductase complex subunit 1 (VKORC1), also known as vitamin K clotting factor deficiency type 2 (VKCFD2), is an integral, 163-amino acid long transmembrane protein. It is encoded by the gene mapped to a 20Mb region on human chromosome 16p12–q21. VKORC1 is widely expressed in various tissues and organs.
Immunogen
Antibody was raised against a 15 amino acid peptide near the amino terminus of human VKORC1.
Biochem/physiol Actions
Vitamin K epoxide reductase complex subunit 1 (VKORC1) enzyme plays a vital role in vitamin K cycle. It catalyzes the conversion of inactive vitamin K to vitamin K hydroquinone, which is crucial for the post-translational γ-carboxylation of vitamin K–dependent clotting factors II (prothrombin), VII, IX, and X. VKORC1 acts as a key target for oral anticoagulants and is also involved in drug metabolism.{4} Genetic variation in the gene leads to warfarin resistance and multiple coagulation factor deficiency type 2.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Linkage
The action of this antibody can be blocked using blocking peptide SBP3500661.
Physical form
Supplied at 1 mg/mL in PBS with 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Product No.
Description
Pricing
Storage Class
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
High prevalence of VKORC1*3 (G9041A) genetic polymorphism in north Indians: A study on patients with cardiac disorders on acenocoumarol.
Sehgal T
Drug Discoveries & Therapeutics (2015)
VKCFD2 - from clinical phenotype to molecular mechanism.
Czogalla KJ
Hamostaseologie (2016)
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Rost S
Nature (2004)
G-1639A but Not C1173T VKORC1 Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population.
Dubovyk YI
BioMed Research International (2016)
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