SAB3500318

Anti-TMEM16A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Ano1, Anti-Anoctamin 1, Anti-Calcium activated chloride channel, Anti-DOG1, Anti-TAOS1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: mouse, human
• technique(s): indirect ELISA: suitable; western blot: suitable
• NCBI accession no.: NP_060513
• UniProt accession no.: Q5XXA6
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ANO1(55107)

Description

General description

Transmembrane member 16A (TMEM16A) or Anoctamin1 (Ano1) is a calcium-activated chloride channel. It is expressed in the interstitial cells of Cajal (ICC) in the gastrointestinal tract. The gene encoding this protein is localized on human chromosome 11q13.3.

Immunogen

TMEM16A antibody was raised against a 17 amino acid peptide from near the amino terminus of human TMEM16A.

Biochem/physiol Actions

Transmembrane member 16A (TMEM16A) or Ano1 is crucial for normal electrical slow waves and for the proliferation of interstitial cells of Cajal (ICC). The protein has a role in smooth muscle contraction, salivary secretion and cardiac and neuronal excitability. TMEM16A has been associated with head and neck squamous cell carcinoma and breast cancer.

Features and Benefits

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500318.

Physical form

Supplied in PBS with 0.02% sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable