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SAB3500204

Sigma-Aldrich

Anti-CX3CR1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-V28

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About This Item

MDL number:
MFCD03096725
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 50 kDa

species reactivity

mouse, human, rat

technique(s)

flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_001328

UniProt accession no.

P49238

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CX3CR1(1524)

General description

C-X3-C motif chemokine receptor 1(CX3CR1) is a seven transmembrane domain G‐protein‐coupled receptor. The gene is located on human chromosome 3p22.2. CX3CR1 is expressed in different types of inflammatory cells.

Immunogen

CX3CR1 antibody was raised against a peptide corresponding to amino acids 2 to 21 of human CX3CR1. The sequence differs from those of mouse and rat CX3CR1 by four amino acids (3,4).

application

Anti-CX3CR1 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

C-X3-C motif chemokine receptor 1 (CX3CR1) functions as a receptor for fractalkine. It is implicated in the progression of inflammatory and vascular disorders.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500204.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Polymorphisms in the microglial marker molecule CX3CR1 affect the blood volume of the human brain
Sakai M, et al.
Psychiatry and Clinical Neurosciences, 72(6), 409-422 (2018)
Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype
Rudyk C, et al.
Journal of Neuroinflammation, 16(1), 120-120 (2019)
Chris Rudyk et al.
Journal of neuroinflammation, 16(1), 120-120 (2019-06-09)
Leucine-rich repeat kinase 2 (LRRK2) is a common gene implicated in Parkinson's disease (PD) and is also thought to be fundamentally involved in numerous immune functions. Thus, we assessed the role of LRRK2 in the context of the effects of
Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures.
Long, et al.
Brain sciences, 13 (2023)
Merlin G Butler et al.
International journal of molecular sciences, 16(3), 6464-6495 (2015-03-25)
Recently, autism-related research has focused on the identification of various genes and disturbed pathways causing the genetically heterogeneous group of autism spectrum disorders (ASD). The list of autism-related genes has significantly increased due to better awareness with advances in genetic

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