SAB3500092

Anti-Seasonal H1N1 Nucleocapsid Protein antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Common flu NP, Anti-NP
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: viral
• technique(s): indirect ELISA: suitable
• NCBI accession no.: ACX46223
• UniProt accession no.: I3QSJ8
• shipped in: dry ice
• storage temp.: −20°C

Description

General description

Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in specimens obtained from patients in Mexico and the United States. The influenza A virus polymerase transcribes and replicates eight virion RNA (vRNA) segments. The nucleocapsid protein (NP) is produced among these segments. It is thought to control whether mRNA or cRNA is produced. NP has multiple functions during the virus life cycle. It possesses regions that are highly conserved among influenza A, B and C viruses. It is studied that NP mutations affected the efficient incorporation of multiple viral-RNA (vRNA) segments into progeny virions. This indicates that the conserved amino acids in NP might be critical for the assembly and incorporation of sets of eight vRNA segments. This antibody is specific for the seasonal H1N1 influenza NP and will not recognize the corresponding NP sequence from the swine-origin H1N1 influenza (A/California/14/2009 (H1N1)).

Immunogen

NP antibody was raised against a synthetic peptide from the Seasonal H1N1 NP protein.

Features and Benefits

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Target description

Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus (S-OIV) was identified in specimens obtained from patients in Mexico and the United States. The influenza A virus polymerase transcribes and replicates eight virion RNA (vRNA) segments, among which the nucleocapsid protein (NP), thought to control whether mRNA or cRNA is produced. The nucleoprotein (NP), which has multiple functions during the virus life cycle, possesses regions that are highly conserved among influenza A, B, and C viruses. It was recently found several NP mutations that affected the efficient incorporation of multiple viral-RNA (vRNA) segments into progeny virions even though a single vRNA segment was incorporated efficiently. This indicates that the respective conserved amino acids in NP may be critical for the assembly and/or incorporation of sets of eight vRNA segments. This antibody is specific for the seasonal H1N1 influenza NP and will not recognize the corresponding NP sequence from the swine-origin H1N1 influenza (A/California/14/2009 (H1N1)).

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500092.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable