SAB2702400

Anti-N-cadherin antibody produced in rabbit

affinity isolated antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: 99kDa
• species reactivity: zebrafish
• concentration: 1mg/mL
• technique(s): immunohistochemistry: 1:100-1:500; western blot: 1:5,000-1:20,000
• isotype: IgG
• shipped in: wet ice
• Storage temp.: −20°C

Description

General description

N-cadherin, also known as cadherin 2 (CDH2), is encoded by the gene mapped to human chromosome 18q11.2. N-Cadherin belongs to the cadherin family. It is highly expressed on the cell membrane of endothelium, nervous and muscular cells.

Immunogen

Recombinant protein encompassing a sequence within the center region of zebrafish N-cadherin.

Application

Suggested starting dilutions are as follows: WB: 1:5000-1:20000, IHC-Wm: 1:100-1:500. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Biochem/physiol Actions

Cadherins plays a vital role in cell-cell adhesion. N-glycosylation of N-cadherin is associated with the process of tumorigenesis especially in mammary gland, renal system and ovary. In addition, N-glycosylation helps in maintaining N-cadherin stability and facilitates glioma migration. Over expression of CDH2 gene was observed in tumor cells. It is known to induce the invasive and chemoresistant attributes to the cancer cells. Loss of expression of the gene was observed in adrenocortical carcinoma. Thus, it can be used as a molecular biomarker in various types of tumoral adrenocortical tissue.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Other Notes

Purification: Purified by antigen-affinity chromatography

Physical form

1XPBS, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

Disclaimer

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable