SAB2700105
Anti-ABCG4 (N-terminal) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
ABCG4, WHITE2
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
western blot: 1:1000-1:10000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ABCG4(64137)
General description
ABCG4 (ATP binding cassette subfamily G member 4) gene is predominantly expressed in central nervous system, specifically in neurons and glia.[1] It is also expressed in megakaryocyte progenitor cells.[2] 72% of amino acids are identical between ABCG1 and ABCG4.[3] The gene is mapped to chromosome 11q23.3.[4]
Immunogen
Recombinant fragment corresponding to a region within amino acids 1 and 201 of ABCG4 according to AAH41091
Application
Suggested starting dilutions are as follows: WB: 1:1000-1:10000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Biochem/physiol Actions
The protein encoded by ABCG4 (ATP binding cassette subfamily G member 4) gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. [provided by RefSeq] ABCG4 maintains sterol homeostasis.[1]
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes
Deng L, et al.
The International Journal of Biochemistry & Cell Biology, 81, 105-111 (2016)
ABCG1 and ABCG4 suppress γ-secretase activity and amyloid β production
Sano O, et al.
PLoS ONE, 11(5), e0155400-e0155400 (2016)
Functional cooperativity between ABCG4 and ABCG1 isoforms
Hegyi Z and Homolya L
PLoS ONE, 11(5), e0156516-e0156516 (2016)
High ABCG4 Expression Is Associated with Poor Prognosis in Non-Small-Cell Lung Cancer Patients Treated with Cisplatin-Based Chemotherapy
Yang G, et al.
PLoS ONE, 10(8), e0135576-e0135576 (2015)
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