Integrin subunit α 11 (ITGA11) is expressed in stromal fibroblasts. Together with the integrin subunit β, it forms a receptor for collagen.
Immunogen
Peptide with sequence PTEEDLSHAPQRNH, from the internal region (near C-terminus) of the protein sequence according to NP_795896.4
Biochem/physiol Actions
Integrin subunit α 11 (ITGA11) may have a role in the organization of interstitial collagen matrices. It has been shown to be upregulated in non-small-cell lung carcinoma. Mice, which are deficient in ITGA11, exhibit signs of dwarfism and malnutrition.
Features and Benefits
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Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells.
Tiger CF
Developmental Biology (2001)
Integrin a11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells
Chang-Qi Zhu
Proceedings of the National Academy of Sciences of the USA (2007)
a11?1 Integrin-Dependent Regulation of Periodontal Ligament Function in the Erupting Mouse Incisor
Svetlana N
Molecular and Cellular Biology (2007)
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