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Key Documents

SAB2501537

Sigma-Aldrich

Anti-GNB3 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

G protein, beta-3 subunit, GTP-binding regulatory protein beta-3 chain, Guanine nucleotide binding protein (G protein), beta polypeptide 3, Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3

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100 μG
$586.00

$586.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
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100 μG
$586.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

$586.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P16520

shipped in

dry ice

Storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GNB3(2784)

General description

The guanine nucleotide binding protein β3 (GNB3) gene is composed of 11 exons and 10 introns. It is the 3 subunit of heterotrimeric G-proteins located on human chromosome 12p13.

Immunogen

Peptide with sequence SGHDNRVSCLGVT, from the internal region of the protein sequence according to NP_002066.1, NP_067642.1

Biochem/physiol Actions

Guanine nucleotide binding protein 3 (GNB3) is involved in the conversion of external receptor activation signals into intracellular signals and it plays an important role in signal transduction pathways. It modulates and associates with favorable antidepressant response. GNB3 takes part in a variety of cellular processes like G protein-coupled receptor signaling.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0456P1
10456P1

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G protein beta 3 gene: structure, promoter, and additional polymorphisms
Rosskopf, D
Hypertension (2000)
Suggestive association between the C825T polymorphism of the G-protein ?3 subunit gene
(GNB3) and clinical improvement with antipsychotics in schizophrenia
Daniel J. Mullerag
Journal of advanced nursing null
Association of a human G-protein beta3 subunit variant with hypertension
Siffert W
Journal of AAPOS : The Official Publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus null
Studies of the association of the GNB3825C>T polymorphism with components of the
metabolic syndrome in white
Danes G. Andersen
Journal of AOAC (Association of Official Analytical Chemists) International null
The cationic region of Rhes mediates its interactions with specific Gbeta subunits
Hill C
Journal of advanced nursing null

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